Risk factors for bone cancer in dogs

Bone cancer in dogs is affected by a variety of genetic risk factors, researchers from Uppsala University and the Broad Institute have found.  They’ve published their results in the journal Genome Biology.
Osteosarcoma, a type of bone cancer, is similar in humans and dogs – although in dogs it is more common.  In the current study, the researchers compared the genome of sick and healthy dogs from three different breeds to find inherited risk factors for the disease.

“The key is that we find many different risk factors within each breed. We already knew that Greyhounds, Rottweilers and Irish wolfhounds are at increased risk of developing bone cancer and our results explain much of the increased risk”, said Emma Ivansson, scientist at SciLifeLab and Uppsala University.

Irish Wolfhound

The study demonstrated that each breed has its own risk genes, but these genes converge in common disease mechanisms.

“Our results show that the pathways involved in bone formation and growth are important for the disease. Because of the great similarities between bone cancer in dogs and humans, we believe that our findings may contribute to an increased understanding of how bone cancer develops in humans”, said Kerstin Lindblad-Toh, professor at Uppsala University and Co-Director of the SciLifeLab and Director of Vertebrate Genome Biology at the Broad Institute.
The researchers are continuing to study the identified risk factors to understand more about how they affect tumor development and to see whether different risk factors respond to different types of treatment.
The researchers are continuing to study the identified risk factors to understand more about how they affect tumor development and to see whether different risk factors respond to different types of treatment. – See more at: http://www.uu.se/en/media/news/article/?id=3103&area=2,10,16&typ=artikel&na=&lang=en#sthash.H1aUoBA8.dpuf

Osteosarcoma, a type of bone cancer, is a rare but very aggressive form of cancer that primarily affects teenagers. Among some large-sized dog breeds the disease is much more common, but otherwise osteosarcoma in humans and dogs is very similar. In the current study, the researchers compared the genome of sick and healthy dogs from three different breeds to find inherited risk factors for the disease.

“The key is that we find many different risk factors within each breed. We already knew that greyhounds, Rottweilers and Irish wolfhounds are at increased risk of developing bone cancer and our results explain much of the increased risk”, said Emma Ivansson, scientist at SciLifeLab and Uppsala University.

The study demonstrated that each breed has its own risk genes, but these genes converge in common disease mechanisms

– See more at: http://www.uu.se/en/media/news/article/?id=3103&area=2,10,16&typ=artikel&na=&lang=en#sthash.H1aUoBA8.dpuf

Bone cancer in dogs is affected by a variety of genetic risk factors. Researchers from Uppsala University and the Broad Institute show this in a new study published in Genome Biology. – See more at: http://www.uu.se/en/media/news/article/?id=3103&area=2,10,16&typ=artikel&na=&lang=en#sthash.H1aUoBA8.dpuf
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