“The key is that we find many different risk factors within each breed. We already knew that Greyhounds, Rottweilers and Irish wolfhounds are at increased risk of developing bone cancer and our results explain much of the increased risk”, said Emma Ivansson, scientist at SciLifeLab and Uppsala University.
The study demonstrated that each breed has its own risk genes, but these genes converge in common disease mechanisms.
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Osteosarcoma, a type of bone cancer, is a rare but very aggressive form of cancer that primarily affects teenagers. Among some large-sized dog breeds the disease is much more common, but otherwise osteosarcoma in humans and dogs is very similar. In the current study, the researchers compared the genome of sick and healthy dogs from three different breeds to find inherited risk factors for the disease.
“The key is that we find many different risk factors within each breed. We already knew that greyhounds, Rottweilers and Irish wolfhounds are at increased risk of developing bone cancer and our results explain much of the increased risk”, said Emma Ivansson, scientist at SciLifeLab and Uppsala University.
The study demonstrated that each breed has its own risk genes, but these genes converge in common disease mechanisms
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