A research team at Mississippi State’s College of Veterinary Medicine is working to better understand cancer in dogs, and the work also could advance knowledge of human cancer.
Their investigation began with only a tiny blood platelet, but quickly they discovered opportunities for growth and expanding the breadth of the research.
“We have a lot to gain by looking at platelets and how they influence cancer and healing,” said Dr. Camillo Bulla. “A part of our research is looking at the platelet. The platelet is very small, but it gives us a large picture. We hope to be able to find a tumor much sooner by taking a series of blood samples to look at platelet contents.”
Bulla is an associate professor in the college’s pathobiology and population medicine department. He and Dr. Kari Lunsford, a colleague at the college, have formed the Comparative Angiogenesis Laboratory at the university to better understand this process and treat canine patients.
As he explained, cancers need the creation of new blood vessels, called angiogenesis, to survive and grow, and tumors are able to create new blood vessels as pathways to travel and spread. They also are looking at the way platelets interact with tumor cells as they attempt to spread to the area surrounding the tumor or metastasize to distant sites in the body.
Lunsford, an associate professor in the clinical sciences department, said, “We know that metastasizing tumor cells need platelets but it is not yet known what the platelets do for the migrating (metastasizing) tumor. This is one of the questions we hope to help answer.”
“If treatments are successful and the cancer goes into remission, we would monitor the patient for a relapse of the disease by looking at its platelets,” Lunsford said. “This type of monitoring would be less invasive than taking biopsies and might also be an earlier indicator that the cancer is returning.”
According to Lunsford, platelets also carry information about tumors and metastasizing cancer cells, and the team hopes that by looking at specific proteins expressed in platelets (from a simple blood sample), they can identify new cancer earlier. Even more importantly, they want to identify when tumors are about to metastasize.
“Our lab has developed a new way to separate platelets from blood samples with far less contamination by other blood cells,” she said. “This new technique was developed by doctoral student Shauna Trichler, and is superior to any isolation technique previously used by researchers in human or veterinary medicine.”
For more information, read the entire Mississippi State University press release here.