It’s a win for Darwin’s Dogs and open access data! A new study published in the journal Science Advances has identified genomic links to the behaviours of herding breeds. The study used data entirely sourced from open-access databases.
Researchers at Korea’s Gyeongsang National University and the U.S. National Institutes of Health analyzed data exclusively from publicly available repositories, including genomic and behavioral data from the community science initiative, Darwin’s Dogs. Their findings are powerful examples of how open science—making research data freely and publicly available—can accelerate discovery by helping scientists leverage existing data in innovative ways.
Herding breeds carry genes linked to cognitive function
Herding breeds like the Australian cattle dog, Belgian Malinois, and border collie have a long history of helping humans move and manage livestock. These dogs are renowned for their precise motor control, sharp intellect, and unwavering drive. In fact, motor patterns required for effective herding—like eyeing, stalking, and chasing animals without killing them—have been so deeply ingrained in herding dogs through generations of selective breeding that even non-working lines often display these traits. But while herding behaviors have been recognized and refined for centuries, their genetic roots have remained largely unknown.
To explore the genetic foundations of herding behaviors, researchers conducted a large-scale genomic comparison across dogs from 12 herding breeds and 91 nonherding breeds. They identified hundreds of genes that have been naturally selected in herding breeds, several of which, through additional analysis, they found linked to cognitive function.
Narrowing their focus to the border collie, a breed celebrated for its intelligence, the research team identified more than eight genes strongly associated with cognition. One of the standouts was EPHB1, a gene involved in spatial memory. Several variants of EPHB1 appeared across herding breed genomes, suggesting that this gene may support the array of complex motor patterns and decision-making skills essential for herding.
Darwin’s Dogs’ database connects genomic discoveries with behavioral insights
Identifying genes associated with breeds is one thing, but understanding their function is another. This is where Darwin’s Dogs’ open-access behavioral and genomic datasets became critical to expanding the impacts of the study’s findings.
Darwin’s Dogs invites dog owners to participate in scientific research by taking behavioral surveys about their dogs and contributing DNA samples for whole genome sequencing. As part of Darwin’s Ark’s open science commitment, this data is de-identified and made available to researchers around the world, creating a unique open-access resource that allows scientists to explore connections between canine DNA and behavioral traits.
The researchers analyzed data from 2,155 dogs in the Darwin’s Dogs database to see whether dogs with the EPHB1 gene behaved differently than dogs without the gene. They found a strong link between EPHB1 and behavior: dogs with this gene were significantly more likely to show toy-oriented behaviors such as stalking, chasing, and grab-biting toys. These actions closely resemble motor patterns seen in herding behaviors.
This link held true even among dogs with mixed breed ancestry, and within border collies from working versus non-working lines, reinforcing the strong connection between EPHB1 and herding-related behaviors.
Open science opens doors to discovery
This study’s discoveries were made possible through open science. Data from open science initiatives like Darwin’s Dogs—and the thousands of community scientists who shared behavioral insights about their dogs—helped researchers connect genomic markers to observable behaviors. The scale and scope of the Darwin’s Dogs database helped the research team analyze behavioral associations to the EPHB1 gene across dogs with varied breed ancestry.
This research serves as a model for how professional researchers and community scientists can come together to accelerate scientific progress. When community scientists contribute to open repositories like Darwin’s Dogs, the possibilities for discovery are endless.
Resources
Read the paper published in Science Advances: Hankyeol Jeong et al. , Genomic evidence for behavioral adaptation of herding dogs. Sci. Adv.11,eadp4591(2025).DOI:10.1126/sciadv.adp4591
Librela, known as Beransa in New Zealand, came onto the market in 2023 in both the USA and New Zealand (it has been introduced earlier in the UK and Europe, in 2021). In late 2023, I shared this post from Dr Darryl Millis about things to consider before choosing to use it with your dog.
Librela/Beransa is an injectable treatment for canine osteoarthritis manufactured by Zoetis.
The drug works by targeting and blocking the action of nerve growth factor, NGF, with a monoclonal antibody called bedinvetmab. NGF is a protein that plays a role in the pain and inflammation associated with osteoarthritis. By binding to NGF, bedinvetmab prevents NGF from activating its receptors on nerve cells, thus blocking the pain signal.
Based on the evaluation and analysis of the reports and signs seen for Librela, the recommendation is to add a Post Approval Experience (PAE) section to the current label:
Post Approval Experience Section (2024) The following adverse events are based on post-approval adverse drug experience reporting for LIBRELA. Not all adverse events are reported to FDA/CVM. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data.
The following adverse events in dogs are categorized in order of decreasing reporting frequency by body system and in decreasing order of reporting frequency within each body system:
Neurologic: ataxia, seizures, paresis, proprioceptive deficits, paralysis General: anorexia, lethargy, recumbency Renal/Urinary: polydipsia, polyuria/pollakiuria, urinary incontinence Gastrointestinal: vomiting, diarrhea Musculoskeletal: muscle weakness, muscle tremors, lameness In some cases, death (including euthanasia) has been reported as an outcome of the adverse events listed above.
In addition, we suggest that owners be advised of the adverse reactions that may occur following administration of Librela.
In the USA, a lawsuit has been filed alleging that Zoetis acted in a negligent manner in promoting its product.
In Australia, a class action lawsuit is being prepared by pet owners who state that their veterinarians described Beransa as a safe and effective drug without known side effects.
Why am I writing this post? To educate and to inform. I’m mindful that many of the commercials for human medications these days remind consumers “All medications have risks and benefits. Talk to your doctor to see if this product is right for you.”
There are veterinarians and dog owners who are reporting good results with this medication, particularly for those dogs who are elderly and for whom other arthritis medications have not worked. If your vet has recommended Beransa, be sure they have explained the possible risks to you and that you are happy to accept those risks on behalf of your dog.
Kathleen Crisley is Fear-Free certified dog massage therapist and canine fitness trainer. She has a particular passion for working with dogs and their families to ensure injury prevention and quality of life. She specialises in working with anxious and emotionally damaged dogs. Her mobile practice, The Balanced Dog, is based in Christchurch, New Zealand
Chances are you either have a dog, know someone with a dog, or spend too much time on the internet watching dog videos. Dogs. Are. Great. Maybe it’s from uniquely coevolving with humans, or maybe it’s because they’re so darn smart, agile, comforting, and cute—but there’s definitely a connection. Whenever we’re on the move, they’re on the move too—and excited about it. Even if it’s just to the kitchen, it is still a fun adventure together.
Any one of us living with a dog (a whopping 60 million—or 45.5%—nationally) has anecdotal evidence to back it up. But how can we measure the ways dogs impact our movement habits and thereby our health and wellness? Katie Potter, Behavioral Medicine Lab director and associate professor of kinesiology, decided to find out.
It all started with a little floppy-eared canine named Chloe. Potter, a slight, brown-haired woman with an athletic frame and a life-long affinity for dogs, adopted the short-haired pup in grad school, and they became inseparable. As someone studying kinesiology and behavioral health, Potter was more aware than most just how much her connection with Chloe improved her wellbeing. Time spent walking and playing with the sweet-tempered Chloe was also time that Potter spent being active and meeting new people in her neighborhood. On bad weather days, people without dogs can be tempted to stay inside in a cozy cocoon of home. But one look at Chloe’s innocent, black-and-white-splotched face had Potter pulling on her boots and reaching for a leash. Chloe also actively helped Potter once she started working in the Behavioral Medicine Lab at UMass, modeling new activity trackers, quality testing the lab treats, and reminding the team to stay in the moment and that, sometimes, you really just need to go for a walk. Potter was a doting pet parent but a scientist through and through.
When Chloe passed away in 2021, Potter had already been inspired by her to research the ways pet ownership might help people become healthier and more active. Motivated by the understanding of how activity levels contribute to or mitigate health conditions like heart disease, type 2 diabetes, and osteoporosis, Potter was convinced that the addition of multiple, small physical activities to a person’s life could lead to big beneficial outcomes. But now, she was even more driven to find out how specifically and find a way to engage a community around a shared love of pet care. Currently, less than 25% of adults in the United States meet the federal guidelines for physical activity. And children aren’t doing any better.
Professor Katie Potter clasps a new activity tracking collar around Percy’s neck while wearing her own for monitoring how close they are to each other.
Dog ownership was a potential avenue to inspire people to move on a grand scale and it excited her. “People are already convinced that animals are good for their health, so we’re trying to determine the evidence base for that,” Potter explains. As she better understands what the impact is from our dog-human bond, she can glean which small actions can be recreated as programs and introduced to the population at large.
Studies show that, to get people to make healthy, lasting changes to their daily routines, those changes need to be ones they actually enjoy. Luckily, a lot of people enjoy canine companionship. So, over the past five years, Potter and doctoral candidate Colleen Sands ’25 have designed observational studies to show how dog ownership affects/impacts physical activity levels, and the effects on specific health issues.
The big question
Does getting a dog make you more active? This is one of the biggest questions Potter is trying to answer. It is equally likely that physically active people get dogs because dogs fit within their already active lifestyle. But how do you test for that?
One of the most difficult parts of this type of experimentation is obtaining data on how active people are before they get a dog. “There’s currently a lack of studies that look at how getting a dog changes the owners’ activity and health—because they’re so logistically challenging,” says Potter. “You have to get data on folks before they bring the dog home and then follow them over time.”
Fortunately, a Massachusetts-based organization called Last Hope K9 Rescue agreed to work with Potter on a 12-week “BuddyStudy.” The study monitored 11 participants for six weeks as they experienced fostering a new dog. Starting out with baseline measurements—their average daily steps and their perceived stress levels or signs of depression (via questionnaires)—Potter was then able to see any noticeable changes at their mid-point check in.
It should be noted that many of the program participants actually ended up adopting their foster dogs through Last Hope K9 Rescue, making the measurements taken at the end of the study all the more interesting. Though it was a small study, the results were promising. Nearly half of the participants saw large increases in physical activity and nearly three-quarters had improvements in mood after fostering their pups. More than half of the participants met someone new in their neighborhood on a dog walk. Most participants adopted their foster dog after the six-week foster period, and some maintained improvements in physical activity and well-being at the end of the study.
With the promising data from that study, Potter was able to see which metrics and methods were the best for helping find answers to her original question—and many others that popped up throughout this experiment. She hopes to do more studies with foster dogs and cats in the future.
An interest in healthy aging
Armed with questions and hypotheses that occurred to her during one of her earliest studies, Project Rover,Potter decided to double down on her interest in how dogs impact physical activity and health in the older population. In Project Rover, Potter had worked with people over the age of 60, but now she wanted to push the age up a bit higher to see how an older generation would be impacted. She recruited 70- to 84-year-olds to be part of a new observational study called the Lifestyle, Brain, and Cognitive Health Study. The participant pool was divided into dog owners and those who were dog-free. Then, for one week, they were asked to go about their normal lives while activity monitors tracked their activity levels. At the end of the week, participants returned to UMass to have a brain scan and take the NIH Toolbox Cognition Battery to test their cognitive function and fluid cognition abilities like problem solving, response time, and ability to adapt to new situations. Ideally, at the end of this type of study, Potter would see improvements across the board with faster response times, more creative problem-solving ideas, and faster transitions to situations.
Though the group size for this study was too small to make generalizations about the results, Potter is excited about the social connection aspect of the study, since most participants said they had met people through their dog and that those people had become friends. The benefit of having the small sample size is that Potter was able to test her methodology, as she plans to conduct wider studies.
What about the kids?
Did you know that the Centers for Disease Control and Prevention (CDC) recommends kids exercise for at least 60 minutes a day? Unfortunately, roughly 40% of children in the United States fall well below that, contributing to a wave of preventable health issues, including mental health impacts. Sands, working on her dissertation under Potter’s tutelage, thought, if we want to create interventions for people, why not start them young? She set out to design the Kids Interacting with Dogs (KID) study, a child-friendly pilot to establish a baseline—starting with children who already had a family dog.
To start, Sands met with participating families over Zoom for orientation. “While the dogs were certainly not required to join the remote study orientation calls,” Sands explains, “most of the kids were really excited to introduce me to their dogs.” Even though it was a remote study, she did get to witness the strong family-dog bond firsthand.
Over a one-week period, the study tracked how frequently kids played with the family dog through data received from Actigraphs—Bluetooth accelerometers that also monitor proximity. Every member of the family wore them (Fido included). And, to Sands’s delight, many of the children immediately decorated the monitors for both them and their dogs. By processing the data coming in, Sands was able to see how many cumulative minutes the kids spent with the dogs, how much they walked, and how actively they played.
Surprisingly, only one-third of the time kids were active with their dog was spent walking and (maybe less surprising to anyone who spends time near children or once was one), the other two-thirds were spent playing. That is notable because adult-focused studies show that owners spend the majority of their active time walking their dog and very little time engaged in play. This kid-specific study opens up new ways to explore the development of future physical activity interventions based on play.
Down the leash
Both Potter and Sands are passionate about finding enjoyable interventions that can improve wellness on a large scale. Potter’s dream is to set up an assistance program that pairs students with older or disabled members of the community who need a little help caring for their dogs. Both the community members and the students would reap the benefits of having a dog in their orbit, as well as experiencing a new, intergenerational human connection.
“One of the cool things about this line of research is that even though physical activity is our primary focus, there are social, emotional, and even academic benefits in human-animal interaction,” Potter shares. “So, there’s the potential for this much more holistic impact.” She says, “This can open up opportunities to areas where we can potentially collaborate with the researchers that are more focused on the animal side of it.” On a grander scale, Potter and Sands hope their research can create a viable, reproducible, scalable public health intervention program based on Potter’s idea. They also hope their research can inform changes around rental properties so people who want to be pet parents can find more housing options.
For now, we can all use these findings to inspire our own interventions. “When the bond is there, people will go to the end of the earth for their pet,” says Potter. It’s heartening to learn that bettering our pets’ lives can improve our own health and wellness too. And they don’t need you to go to the end of the earth for them—just to the end of the block.
Coming through the door from a hard day’s work to be greeted by the irrepressible joy of a dog bounding towards you, like they haven’t seen you in years, can be as satisfying as returning to an actual human partner, according to a new study.
Raising a furry companion like a cat or dog can bring you the same psychological benefits as getting married or earning an extra £70,000 a year, researchers at Kent University have found.
Using the “life satisfaction” approach, economists can translate intangible assets like friendship and family into a hypothetical income.
The research conducted on 2,500 British families found that owning a pet was linked to an increase in life satisfaction of 3-4 points on a scale of 1-7, similar to values obtained for meeting with friends and relatives regularly.
The study’s authors say they suspect that many people don’t actually realise how important their pets are for them (Getty Images/iStockphoto)
Economists have shown that marriage, compared to being single, is worth around £70,000 a year. Separation, on the other hand, is equivalent to around minus £170,000 a year.
Dr Adelina Gschwandtner of the University of Kent, the lead author of the new study, toldThe Timesshe was inspired by a paper that put a price tag on human friendship.
“I thought, ‘well, if it’s possible for friends, why not for pets?’”
“I understand why some people might be sceptical [about the £70,000 value],” she said.
“Given that pets are considered by many as best friends and family members, these values appear to be plausible … I also suspect that many people don’t actually realise how important their pets are for them.”
Simply stroking our pets can lower the levels of the stress hormone cortisol in our bodies, leading to a calmer approach to life and thus positively impacting our blood pressure and make you less likely to suffer from clinical depression.
Dr Gschwandtner added: “This research answers the question whether overall pet companions are good for us with a resounding ‘Yes’.
“Pets care for us and there is a significant monetary value associated with their companionship. This information can be used for health care practice and policy aiming to increase well-being and life satisfaction of humans involving pets.”
The research follows a 2022 Pets at Home study that found more than one-quarter of people asked preferred to see their pet over their partner after a day at work.
Loneliness has become an increased concern nationally since the pandemic. However, studies have shown companionship with dogs can greatly reduce the effects. (VCU Center of Human-Animal Interaction)
Long known as man’s best friend, dogs are being embraced even more now as a means of combatting loneliness. In one study, frequent interactions with dogs, either through ownerships or through long-term interventions, have been associated with positive psychological outcomes across the human lifespan.
“They are skilled at socializing with humans, sensitive to our emotional states and gestures – they can communicate using complex cues and form complex attachment relationships with humans,” said Nancy Gee, Ph.D., C-AISS, professor of psychiatry and the director of Virginia Commonwealth University’s Center for Human-Animal Interaction and Bill Balaban Chair in Human-Animal Interaction. “Their attachment to their human owners mirrors that of human babies to their mothers.”
Gee, whose been studying the relationship between therapy dogs and humans for more than two decades, spoke with VCU Health News about how interactions with dogs can relieve loneliness and increase connection with others.
How can dogs combat human loneliness?
Dogs are thought to fulfill the four roles of an attachment figure: They are enjoyable, comforting, missed when absent and sought in times of distress. Adults and children alike confide in their pets because they relieve us from the worry of confidentiality, judgments, or meeting expectations.
When humans interact with a dog in a calm way – where they are stroking the dog and making eye contact, or even talking to the dog – we see that both species release oxytocin (bonding/feel-good hormone), and their cortisol (stress hormone) levels drop. Additionally, their blood pressure and muscle tension lower, and their mood elevates.
When you combine these responses together, it indicates the interactions are relaxing and enjoyable, which helps to reduce a person’s overall experience of loneliness.
Is there a difference from other animals?
Probably, yes, but there is not enough research on the subject to know for certain. We do know that dogs are unique in the animal kingdom. Through domestication and selection, dogs emerged from the grey wolf over a period of at least 35,000 years, and there is probably no other species on the planet as well-matched to human social needs as dogs.
What are common types of service dogs, and do they differ in addressing human loneliness?
There are three prominent classifications:
A Service Dog (also called an Assistance Dog) has one handler who has a medically recognized disability. The dog is specially trained to assist that one person (their handler) with some aspect of that disability. For example, some dogs are trained to alert a person with a seizure disorder that a seizure is about to occur. This will allow the person to take medicine, call for assistance and/or get into a safe place/position so that they are not harmed during the actual seizure. Service Dogs are covered under the American’s with Disabilities Act and are granted access to public facilities and housing that otherwise excludes pets.
An Emotional Support Animal can be any animal species and requires no specific training. An ESA supports one person with a mental disability by comforting that person in a way that reduces symptoms. ESA status is determined by a mental health professional who writes a letter attesting to the animal’s role and housing status if pets are otherwise not allowed. However, ESAs are not permitted any other public access.
A Therapy Dog is handled by one person, but the dog’s job is to interact with many people who may benefit from the interaction. Therapy dogs, like those in our center’s Dogs on Call program, are granted access to facilities and transportation based on the permission of the administration of the facility or transportation provider, and the requirements of the program in which the dogs participate.
Currently, there is very little research that compares the three classifications of animals and the effects of SDs or ESAs in reducing loneliness. However, Dogs on Call specifically, and other therapy dogs in general, have been found to significantly reduce loneliness in the people they visit.
Does human age matter in regard to loneliness and the benefits of interacting with dogs?
We have results back from our own randomized clinical trials showing that for older adults and for adults with mental illness, interacting with Dogs on Call dogs and handlers is effective at reducing loneliness.
We’ve just completed data collection on our pediatric study, so we don’t know the answer just yet, but we have reason to believe that across the human lifespan, interacting with a therapy dog can reduce loneliness. Additionally, one study showed that adolescents derive more satisfaction from, and engage in less conflict with, their pets than with their human siblings.
Source: VCU Health (Virginia Commonwealth University)
The ASPCA Poison Control Center has released its Top 10 list for reports of poisoning in pets during 2024. This list is a good guide for pet parents on safety.
The top items that are ingested are over-the-counter medications and supplements. Be careful when taking these items to ensure that any pills which are dropped on the floor are picked up immediately and that bottles are stored away from a dog’s reach.
Not all human foods are suitable for our dogs – notably things like grapes and raisins, xylitol-containing sweets and peanut butters are good examples. Be careful in the kitchen and pick up spills immediately. In my practice, I have seen a rise in incidents involving peanut butter that contains xylitol. It’s really important to read the label before giving your dog peanut butter and, if you share food, you must remember that not everyone bakes with xylitol-free peanut butter!
Chocolate is a well-known risk and ingestions of chocolate often occur over holidays like Christmas and Easter and during other family celebrations like birthdays. Your dog will follow its nose – so chocolates should not be kept in bags and jacket pockets.
Try to be gentle on the Earth and opt for more natural options instead of chemical pesticides; this will limit exposure risk in pets. And if using rodenticides, follow the instructions and use bait inside approved traps.
Let’s hope all my readers have a 2025 without incidents of poisoning!
There is a growing awareness of the link between overall health and a healthy gut. If gut health is poor, your dog will not thrive. Whilst diet is the first port of call for good health, dog owners are also seeking to augment diet with the ”right” additions to food.
Prebiotics and probiotics offer support for gut health, but I find that dog owners can often confuse the two terms.
A healthy gastrointestinal tract contains an abundance of beneficial bacteria that help digest food into nutrients which the body then absorbs. These bacteria are probiotics; the most common strains are the Lactobacillis and Bifidobacterium families of bacteria. Probiotics are available in supplement form – too many brands to mention in this column!
Prebiotics are fermentable fibres that support the growth of the good bacteria. When the fibre reaches the large intestine, the bacteria are able to ferment certain types of fibre which result in short-chain fatty acids. These fatty acids support and protect the intestinal lining, help reduce inflammation and prevent the overgrowth of unwanted bacteria. Examples of prebiotics are beet pulp which is an ingredient in many commercial foods and psyllium husk.
Psyllium husk is my prebiotic of choice for managing Sox’s inflammatory bowel disease
A healthy bowel is able to absorb more nutritional value from food.
When should you consider the addition of prebiotics and probiotics? Conditions that respond well include:
Inflammatory bowel disease
Stress-related diarrhoea
Antibiotic-associated diarrhoea
Dietary intolerances
When the intestinal tract is working well, faecal odours are less and stool consistency improves. You will notice the difference when picking up after your dog – particularly if you have been managing soft stools and diarrhoea for extended periods of time.
Kathleen Crisley is Fear-Free certified dog massage therapist and canine fitness trainer. She has a particular passion for working with dogs and their families to ensure injury prevention and quality of life. She specialises in working with anxious and emotionally damaged dogs. Her mobile practice, The Balanced Dog, is based in Christchurch, New Zealand
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