Tag Archives: PLoS ONE

Do sterilized dogs live longer?

New research from the University of Georgia suggests that neutering procedures could add to the length of a dog’s life and alter the risk of specific causes of death.

Looking at a sample of 40,139 death records from the Veterinary Medical Database from 1984-2004, researchers determined the average age at death for intact dogs—dogs that had not been spayed or neutered—was 7.9 years versus 9.4 years for sterilized dogs.

These figures may seem low considering how many pets live much longer, but the researchers noted that the life spans would be lower than those seen more widely because their sample was taken from dogs seen at teaching hospitals (so other things would have been going on and the study population would have had more sick animals).

The researchers stand behind their results – that the difference between neutered and intact is real.

Dr. Kate Creevy, an assistant professor of internal medicine at the College of Veterinary Medicine. “The question that raises is why would you die younger if you have offspring?”

For the first time, researchers have been able to measure costs of reproduction in terms of the actual causes of death, finding that the causes of death differed between sterilized and intact dogs. Dogs who had undergone a gonadectomy (a spay or castration) were more likely to die from cancer or autoimmune diseases. Those in the sample who still had functional reproduction systems at death were more likely to die from infectious disease and trauma.

“Intact dogs are still dying from cancer; it is just a more common cause of death for those that are sterilized,” said Jessica Hoffman, a UGA doctoral candidate in the Franklin College of Arts of Sciences who co-authored the study.

Some of the reproductive hormones, particularly progesterone and testosterone, she said, could suppress the immune system, explaining why there is an increased risk of infection among dogs that have been sterilized.

The full journal article, published in PLoS One, can be viewed here.

Source:  University of Georgia media statement

One of the first domestic dogs revealed

DNA technology is being used to refine our understanding of when the domestic dog became a separate genetic line from wolves.

Wolf

In latest research, published in the open access journal PLoS ONE, DNA analysis on a 33,000-year old dog is reported.  DNA was extracted from a tooth.

The analyses show that the dog, from the Altai region which is east of Kazakhstan and north of China and Mongolia, is more closely related to modern dogs than contemporary wolves.  The research team, led by Anna Druzhkova from the Institute of Molecular and Cellular Biology in the Russian Federation, report that genetic analyses of ancient canids may help to reveal a more exact date and centre of domestication for the dog.

While it is widely accepted that the dog domestication predates the beginning of agriculture (about 10,000 years ago), no one can be sure when the genetics of wolves and domestic dogs began to diverge.

Source:  PLoS ONE

Dogs are a ‘social lubricant’ in helping people with autism

Research published in the open access journal PLoS ONE indicates that the presence of an animal can significantly increase positive social behaviors in children with autism spectrum disorders (ASD).

Autistic boy with dog

Previous studies have shown that people are more likely to receive overtures of friendship from strangers when walking a dog than when walking alone. The authors suggest that this ‘social lubricant’ effect of animals on human social interactions can be particularly important for individuals with socio-emotional disabilities.

In this study, the authors compared how 5-13 year old children with ASD interacted with adults and typically-developing peers in the presence of two guinea pigs compared to toys.  When the guinea pigs were present, the children were more likely to talk and look other people in the eye plus they smiled and laughed more often.

These results indicate that animal-assisted therapy programmes may be useful in helping children with ASD integrate into classrooms and other social environments.

Source:  Science Daily

How your dog matches words to objects

Researchers at the University of Lincoln (UK) have published a study based on the learning patterns of a Border Collie named Gable.  They wanted to see if Gable could match words with objects based on shape, which is the learning pattern in humans of toddler age.

Credit: Sally Smith; van der Zee E, Zulch H, Mills D (2012) Word Generalization by a Dog (Canis familiaris): Is Shape Important?

Gable could identify an object by name, but over time he associated the same word with objects of similar texture or size (not shape).

The researchers concluded that where shape matters for humans, size or texture appears to be the dominating issue for a dog.

This is small study (using only one dog) but it does provide insight into the learning and development of dogs.  I’m sure there is more to come in this research field.

Source:  Word Generalization by a Dog (Canis familiaris): Is Shape Important?

Tail chasing – an obsessive compulsive disorder?

The genetics research group at the University of Helsinki has published its findings into a study of tail chasing in dogs.  The study involved 400 dogs and questionnaires to the owners about their dog’s behaviour.  Samples of each dog’s blood were also taken.

The questionnaires covered behaviours, aspects of the dog’s puppyhood and daily routines.  Owners were also asked to evaluate their dog’s personality.

Compulsive tail chasing can occur in any dog but is common in breeds such as the Bull Terrier and German Shepherd.  These breeds were included in the research, as were the Miniature Bull Terrier and the Staffordshire Bull Terrier.

The study aimed to describe the characteristics of tail chasing in dogs and to ascertain the environmental risk factors for the disorder.  The researchers also wanted to know if a previously identified gene that has been associated with obsessive compulsive disorder (OCD)  had a role to play.

What they found

  • The OCD gene that had been linked to other compulsive disorders in dogs was not associated with the tail chasing disorder
  • Dogs responded with less tail chasing when fed supplements of vitamins and minerals, although the researchers feel that more study is warranted to prove this link
  • Early separation from their mothers and/or poor care from their mother also predisposed dogs to compulsive tail chasing

Dogs may be a good model for studying OCD in humans because they are physiologically similar and share our environment.  Consequently, this research has wider implications.

The research paper is available in the 27 July 2012 edition of PloS ONE

Source:  University of Helsinki press release

Kathleen Crisley, Fear-Free certified professional and specialist in dog massage, rehabilitation and nutrition/food therapy, The Balanced Dog, Christchurch, New Zealand

Epilepsy gene discovery in dogs

The journal PLoS ONE has published research this week by Professor Hannes Lohi of the University of Helsinki.  Professor Lohi and his research team have isolated a gene linked to epilepsy in Belgian Shepherds.

The gene is found on canine chromosome 37.  The research team isolated the gene by comparing the genome of dogs with epilepsy against those of dogs that were in a healthy control group.  The gene could increase the risk of epilepsy by a factor of 7.

Genetic epilepsy is also referred to as ‘idiopathic epilepsy.’  A co-author on the article has said that as many as 20% of the Belgian Shepherd breed is estimated to have epilepsy and so the research could underpin the development of a genetic test for the disease.

Seizures can result in abnormal movements, usually on one side of the body, followed by cramping in the limbs.  Drooling and vomiting are other symptoms.

This research group is responsible for other genetic discoveries in dogs.  Through their research, the group has developed a canine DNA bank in Finland containing 40,000 samples from 250 different breeds of dogs.  They have previously identified the epilepsy gene EPM2B in Miniature Wirehaired Dachshunds and a gene LGI2 in Lagotto Romagnolos and collaborated with other researchers in the discovery of an epilepsy gene in Tibetan Terriers.

Source:  Helsingin yliopisto (University of Helsinki) (2012, March 23).   New epilepsy gene located in dogs. ScienceDaily. Retrieved March 25, 2012, from http://www.sciencedaily.com­ /releases/2012/03/120323205337.htm?utm_source=feedburner&utm_medium=email&utm_campaign=Feed%3A+sciencedaily%2Fplants_animals%2Fdogs
+%28ScienceDaily%3A+Plants+%26+Animals+News+–+Dogs%29